Metagenomic Analysis of the Gut Microbiome Reveals Enrichment of Menaquinones (Vitamin K2) Pathway in Diabetes Mellitus.

ABSTRACT:

Background

Type 2 diabetes mellitus (T2DM) is a chronic metabolic disease with a high prevalence worldwide, especially among overweight and obese populations. T2DM is multifactorial with several genetic and acquired risk factors that lead to insulin resistance. Mounting evidence indicates that alteration of gut microbiome composition contribute to insulin resistance and inflammation. However, the precise link between T2DM and gut microbiome role and composition remains unknown.

Methods

We evaluated the metabolic capabilities of the gut microbiome of twelve T2DM and six healthy individuals through shotgun metagenomics using MiSeq platform.

Results

We identified no significant differences in the overall taxonomic composition between healthy and T2DM subjects when contro

SUBMITTER: Dash NR 

PROVIDER: S-EPMC7850878 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature