Behavioral, neuroanatomical, and molecular correlates of resilience and susceptibility to maternal immune activation.

ABSTRACT: Infectious or noninfectious maternal immune activation (MIA) is an environmental risk factor for psychiatric and neurological disorders with neurodevelopmental etiologies. Whilst there is increasing evidence for significant health consequences, the effects of MIA on the offspring appear to be variable. Here, we aimed to identify and characterize subgroups of isogenic mouse offspring exposed to identical MIA, which was induced in C57BL6/N mice by administration of the viral mimetic, poly(I:C), on gestation day 12. Cluster analysis of behavioral data obtained from a first cohort containing >150 MIA and control offspring revealed that MIA offspring could be stratified into distinct subgroups that were characterized by the presence or absence of multiple behavioral dysfunctions. The two subgro

SUBMITTER: Mueller FS 

PROVIDER: S-EPMC7850974 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature