Endotoxemia by Porphyromonas gingivalis Alters Endocrine Functions in Brown Adipose Tissue.

ABSTRACT: Improvement of obesity is important for increasing longevity. The characteristics, size, and function of adipocytes are altered in patients with obesity. Adipose tissue is not only an energy storage but also an endocrine organ. Alteration of endocrine activities in adipose tissue, among them the functional decline of brown adipose tissue (BAT), is associated with obesity. Periodontal disease is a risk factor for systemic diseases since endotoxemia is caused by periodontal bacteria. However, the effect of periodontal disease on obesity remains unclear. Thus, this study aimed to investigate the effect of endotoxemia due to Porphyromonas gingivalis, a prominent cause of periodontal disease, on the BAT. Herein, endotoxemia was induced in 12-week-old C57BL/6J mice through intravenous inj

SUBMITTER: Hatasa M 

PROVIDER: S-EPMC7850987 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature