Microtubule Stabilization Promotes Microcirculation Reconstruction After Spinal Cord Injury.

ABSTRACT: Spinal cord microcirculation plays an important role in maintaining the function of spinal cord neurons and other cells. Previous studies have largely focused on the ability of microtubule stabilization to inhibit the fibroblast migration and promote axon regeneration after spinal cord injury (SCI). However, the effect of microtubule stabilization treatment on microcirculation reconstruction after SCI remains unclear. By using immunofluorescence, we found that microtubule stabilization treatment improved microcirculation reconstruction via increasing the number of microvessels, pericytes, and the perfused microvessels after SCI. To clarify the underlying mechanisms, rat brain microvascular endothelial cells and pericytes were subjected to glucose oxygen deprivation. By using flow cytometry

SUBMITTER: Duan YY 

PROVIDER: S-EPMC7851021 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature