Gut Commensal-Induced IκBζ Expression in Dendritic Cells Influences the Th17 Response.

ABSTRACT: Intestinal commensal bacteria can have a large impact on the state of health and disease of the host. Regulation of Th17 cell development by gut commensals is known to contribute to their dichotomous role in promoting gut homeostasis and host defense, or development of autoimmune diseases. Yet, the underlying mechanisms remain to be fully elucidated. One candidate factor contributing to Th17 differentiation, and the expression of which could be influenced by commensals is the atypical nuclear IκB protein IκBζ. IκBζ acts as a transcriptional regulator of the expression of Th17-related secondary response genes in many cell types including dendritic cells (DCs). Insights into the regulation of IκBζ in DCs could shed light on how these immune sentinel cells at the interface between commensals,

SUBMITTER: Michaelis L 

PROVIDER: S-EPMC7851057 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature