Genetic aberrations in DNA repair pathways: a cornerstone of precision oncology in prostate cancer.

ABSTRACT: Over the past years, several studies have demonstrated that defects in DNA damage response and repair (DDR) genes are present in a significant proportion of patients with prostate cancer. These alterations, particularly mutations in BRCA2, are known to be associated with an increased risk of developing prostate cancer and more aggressive forms of the disease. There is growing evidence that certain DDR gene aberrations confer sensitivity to poly-(ADP ribose) polymerase inhibitors and/or platinum chemotherapy, while other defects might identify cases that are more likely to benefit from immune checkpoint inhibition. The potential prognostic impact and relevance for treatment selection together with the decreasing costs and broader accessibility to next-generation sequencing have already resu

SUBMITTER: Lozano R 

PROVIDER: S-EPMC7851123 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature