Role of lysophosphatidic acid and its receptors in health and disease: novel therapeutic strategies.

ABSTRACT: Lysophosphatidic acid (LPA) is an abundant bioactive phospholipid, with multiple functions both in development and in pathological conditions. Here, we review the literature about the differential signaling of LPA through its specific receptors, which makes this lipid a versatile signaling molecule. This differential signaling is important for understanding how this molecule can have such diverse effects during central nervous system development and angiogenesis; and also, how it can act as a powerful mediator of pathological conditions, such as neuropathic pain, neurodegenerative diseases, and cancer progression. Ultimately, we review the preclinical and clinical uses of Autotaxin, LPA, and its receptors as therapeutic targets, approaching the most recent data of promising molecules modul

SUBMITTER: Geraldo LHM 

PROVIDER: S-EPMC7851145 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature