Serum lipid profiles and risk of colorectal cancer: a prospective cohort study in the UK Biobank.

ABSTRACT:

Background

It remains unclear whether serum lipids influence colorectal cancer (CRC) risk.

Methods

We conducted a prospective cohort study of 380,087 adults aged 40-69 years in the UK Biobank. Serum high-density cholesterol, low-density cholesterol, total cholesterol, triglycerides, and apolipoprotein A and B were measured. We used Cox proportional hazard models to estimate the multivariable hazard ratios (HRs) of CRC according to one standard deviation (SD) increment in serum lipids. We conducted subgroup analysis by tumour anatomical subsites.

Results

During a median of 10.3 years of follow-up, we documented 2667 incident CRC cases. None of the lipid biomarkers was associated with the risk of CRC after adjusting for potential confounding factors, including body mass

SUBMITTER: Fang Z 

PROVIDER: S-EPMC7851156 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature