Molecular characterization of a marine turtle tumor epizootic, profiling external, internal and postsurgical regrowth tumors.

ABSTRACT: Sea turtle populations are under threat from an epizootic tumor disease (animal epidemic) known as fibropapillomatosis. Fibropapillomatosis continues to spread geographically, with prevalence of the disease also growing at many longer-affected sites globally. However, we do not yet understand the precise environmental, mutational and viral events driving fibropapillomatosis tumor formation and progression.Here we perform transcriptomic and immunohistochemical profiling of five fibropapillomatosis tumor types: external new, established and postsurgical regrowth tumors, and internal lung and kidney tumors. We reveal that internal tumors are molecularly distinct from the more common external tumors. However, they have a small number of conserved potentially therapeutically targetable molecula

SUBMITTER: Yetsko K 

PROVIDER: S-EPMC7851172 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature