Use of trihalomethanes as a surrogate for haloacetonitrile exposure introduces misclassification bias.

ABSTRACT: Epidemiologists have used trihalomethanes (THMs) as a surrogate for overall disinfection byproduct (DBP) exposure based on the assumption that THM concentrations are proportional to concentrations of other DBP classes. Toxicological evidence indicates THMs are less potent toxins than unregulated classes like haloacetonitriles (HANs). If THMs are not proportional to the DBPs driving toxicity, the use of THMs to measure exposure may introduce non-trivial exposure misclassification bias in epidemiologic studies. This study developed statistical models to evaluate the covariance and proportionality of HAN and THM concentrations in a dataset featuring over 9500 measurements from 248 public water systems. THMs only explain ∼30% of the variance in HANs, whether the data is pooled in a classic lin

SUBMITTER: Furst KE 

PROVIDER: S-EPMC7851183 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature