Production, purification, and radiolabeling of the ²⁰³Pb/²¹²Pb theranostic pair.

ABSTRACT:

Background

Lead-212 (²¹²Pb, t_1/2 = 10.6 h) and lead-203 (²⁰³Pb, t_1/2 = 51.9 h) are an element-equivalent, or a matched theranostic radioisotope pair that show great potential for application in targeted radionuclide therapy (TRT) and single-photon emission computed tomography (SPECT), respectively. At TRIUMF we have produced both ²⁰³Pb and ²¹²Pb using TRIUMF's TR13 (13 MeV) and 500 MeV cyclotrons, and subsequently purified and evaluated both radioisotopes using a series of pyridine-modified DOTA analogues in comparison to the commercially available chelates DOTA (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid) and TCMC (1,4,7,10-tetraaza-1,4,7,10-tetra(2-carbamoylmethyl)cyclododecane).

Results

Proton

SUBMITTER: McNeil BL 

PROVIDER: S-EPMC7851237 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature