Assessment of fecal calprotectin and fecal occult blood as point-of-care markers for soil-transmitted helminth attributable intestinal morbidity in a case-control substudy conducted in Cote d'Ivoire, Lao PDR and Pemba Island, Tanzania.

ABSTRACT:

Background

Infections with soil-transmitted helminths (STHs) may result in chronic inflammatory disorders affecting the human host. The objective of this study was to evaluate Fecal Calprotectin (FC) and Fecal Occult Blood (FOB) in individuals infected and non-infected with STHs to identify potential intestinal morbidity markers.

Methods

Stool from participants diagnosed positive for Trichuris trichiura and concomitant STH infections from three countries was used to perform FC and FOB point-of-care assays. Simultaneously, identified STH negative participants underwent FC and FOB testing as controls. Potential associations between test results and determinants were analyzed using multivariable logistic regression.

Findings

In total, 1034 T. trichiura infe

SUBMITTER: Patel C 

PROVIDER: S-EPMC7851339 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature