Novel Aza-podophyllotoxin derivative induces oxidative phosphorylation and cell death via AMPK activation in triple-negative breast cancer.

ABSTRACT:

Background

To circumvent Warburg effect, several clinical trials for different cancers are utilising a combinatorial approach using metabolic reprogramming and chemotherapeutic agents including metformin. The majority of these metabolic interventions work via indirectly activating AMP-activated protein kinase (AMPK) to alter cellular metabolism in favour of oxidative phosphorylation over aerobic glycolysis. The effect of these drugs is dependent on glycaemic and insulin conditions.  Therefore, development of small molecules, which can activate AMPK, irrespective of the energy state, may be a better approach for triple-negative breast cancer (TNBC) treatment.

Methods

Therapeutic effect of SU212 on TNBC cells was examined using in vitro and in vivo models.

Results

We de

SUBMITTER: Tailor D 

PROVIDER: S-EPMC7851402 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature