Relationships between serum electrolyte concentrations and ileus: A joint clinical and mathematical modeling study.

ABSTRACT:

Aim

Prolonged postoperative ileus (PPOI) occurs in around 15% of patients after major abdominal surgery, posing a significant clinical and economic burden. Significant fluid and electrolyte changes may occur peri-operatively, potentially contributing to PPOI; however, this association has not been clearly elucidated. A joint clinical-theoretical study was undertaken to evaluate peri-operative electrolyte concentration trends, their association with ileus, and predicted impact on bioelectrical slow waves in interstitial cells of Cajal (ICC) and smooth muscle cells (SMC).

Methods

Data were prospectively collected from 327 patients undergoing elective colorectal surgery. Analyses were performed to determine associations between peri-operative electrolyte concentrations and prol

SUBMITTER: Penfold JA 

PROVIDER: S-EPMC7851429 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature