FTO modifies the m6A level of MALAT and promotes bladder cancer progression.

ABSTRACT:

Background

Nearly a half million people around the world are diagnosed with bladder cancer each year, and an incomplete understanding of its pathogenicity and lack of efficient biomarkers having been discovered lead to poor clinical management of bladder cancer. Fat mass and obesity-associated protein (FTO) is a critical player in carcinogenesis. We, here, explored the role of FTO and unraveled the mechanism of its function in bladder cancer.

Methods

Identification of the correlation of FTO with bladder cancer was based on both bioinformatics and clinical analysis of tissue samples collected from a cohort of patients at a hospital and microarray data. Gain-of-function and loss-of-function assays were conducted in vivo and in vitro to assess the effect of FTO on bladder carci

SUBMITTER: Tao L 

PROVIDER: S-EPMC7851431 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature