Harnessing NK cells for cancer immunotherapy: immune checkpoint receptors and chimeric antigen receptors.

ABSTRACT: Natural killer (NK) cells, key antitumor effectors of the innate immune system, are endowed with the unique ability to spontaneously eliminate cells undergoing a neoplastic transformation. Given their broad reactivity against diverse types of cancer and close association with cancer prognosis, NK cells have gained considerable attention as a promising therapeutic target for cancer immunotherapy. NK cell-based therapies have demonstrated favorable clinical efficacies in several hematological malignancies but limited success in solid tumors, thus highlighting the need to develop new therapeutic strategies to restore and optimize anti-tumor activity while preventing tumor immune escape. The current therapeutic modalities yielding encouraging results in clinical trials include the blockade of

SUBMITTER: Kim N 

PROVIDER: S-EPMC7851441 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature