Possible Modulatory Role of ARC Gene Variants in Mood Disorders.

ABSTRACT:

Objective

The genetic background of mood disorders is gradually emerging through the use of large multicenter samples but a detailed phenotyping is complementary in elucidating the role of modulating variants.

Methods

In the present paper we focused on the possible modulatory effects of ARC gene variants on two independent mood disorder samples of European (n = 246 bipolar disorder) and Korean (n = 132 bipolar disorder; n = 242 major depressive disorder [MDD]) ancestry.

Results

No result survived Bonferroni correction, however we evidenced promising trend toward possible association between ARC gene variants and mood disorder phenotypes. In particular, we evidenced weak correlations of ARC single nucleotide polymorphisms with depressive symptoms severity (evaluated th

SUBMITTER: Crisafulli C 

PROVIDER: S-EPMC7851469 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature