Single-cell RNA-sequencing analyses identify heterogeneity of CD8⁺ T cell subpopulations and novel therapy targets in melanoma.

ABSTRACT: CD8⁺ T cells are crucial to establish antitumor immunity, and their high infiltration associates with favorable prognoses. However, several CD8⁺ T cell subpopulations in the tumor microenvironment may play different roles in prognosis, progression, and immunotherapy. Here, we analyzed prior published single-cell RNA-sequencing (scRNA-seq) melanoma data to explore the heterogeneity of CD8⁺ T cell subpopulations and identified 7 major subpopulations. We found that high infiltration of exhausted CD8⁺ T cell subpopulation 2 would contribute to unfavorable prognoses. In contrast, a large proportion of naive/memory cells and cytotoxic CD8⁺ T cell subpopulation 3 would lead to favorable prognoses. Notably, the proportion of the cytotoxic CD8<

SUBMITTER: Deng W 

PROVIDER: S-EPMC7851490 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature