Effect of redundant clinical trials from mainland China evaluating statins in patients with coronary artery disease: cross sectional study.

ABSTRACT:

Objective

To identify redundant clinical trials evaluating statin treatment in patients with coronary artery disease from mainland China, and to estimate the number of extra major adverse cardiac events (MACEs) experienced by participants not treated with statins in those trials.

Design

Cross sectional study.

Setting

2577 randomized clinical trials comparing statin treatment with placebo or no treatment in patients with coronary artery disease from mainland China, searched from bibliographic databases to December 2019.

Participants

250 810 patients with any type of coronary artery disease who were enrolled in the 2577 randomized clinical trials.

Main outcome measures

Redundant clinical trials were defined as randomized clinical trials that initiated or c

SUBMITTER: Jia Y 

PROVIDER: S-EPMC7851709 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature