Effects of fructose restriction on liver steatosis (FRUITLESS); a double-blind randomized controlled trial.

ABSTRACT:

Background

There is an ongoing debate on whether fructose plays a role in the development of nonalcoholic fatty liver disease.

Objectives

The aim of this study was to investigate the effects of fructose restriction on intrahepatic lipid (IHL) content in a double-blind randomized controlled trial using an isocaloric comparator.

Methods

Between March 2017 and October 2019, 44 adult overweight individuals with a fatty liver index ≥ 60 consumed a 6-wk fructose-restricted diet (<7.5 g/meal and <10 g/d) and were randomly assigned to supplementation with sachets of glucose (= intervention group) or fructose (= control group) 3 times daily. Participants and assessors were blinded to the allocation. IHL content, assessed by proton magnetic resonance spectroscopy, was the prima

SUBMITTER: Simons N 

PROVIDER: S-EPMC7851818 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature