Modality-specific dysfunctional neural processing of social-abstract and non-social-concrete information in schizophrenia.

ABSTRACT: Schizophrenia is characterized by marked communication dysfunctions encompassing potential impairments in the processing of social-abstract and non-social-concrete information, especially in everyday situations where multiple modalities are present in the form of speech and gesture. To date, the neurobiological basis of these deficits remains elusive. In a functional magnetic resonance imaging (fMRI) study, 17 patients with schizophrenia or schizoaffective disorder, and 18 matched controls watched videos of an actor speaking, gesturing (unimodal), and both speaking and gesturing (bimodal) about social or non-social events in a naturalistic way. Participants were asked to judge whether each video contains person-related (social) or object-related (non-social) information. When processing so

SUBMITTER: He Y 

PROVIDER: S-EPMC7851842 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature