An edge-based statistical analysis of long non-coding RNA expression profiles reveals a negative association between Parkinson's disease and colon cancer.

ABSTRACT:

Background

Colon cancer (CC) is one of the most common malignant tumors, while Parkinson's disease (PD) is the second most common neurodegenerative disorder. Recent accumulating evidence indicates that these two diseases are associated with each other. Also, from the perspective of long non-coding RNAs, some well-known genes such as H19 and PVT1 can link these two diseases together. Several studies have shown that patients with PD had a decreased risk of developing CC compared with patients without PD. However, controversies surround the relationship between PD and CC, and to date, no concordant conclusion has been drawn.

Methods

In this study, we aimed to assess the association between these two diseases based on lncRNA-to-lncRNA interactions. Motivated by the weighted gene

SUBMITTER: Tian S 

PROVIDER: S-EPMC7851899 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature