Incidence and management of metabolic acidosis with sodium bicarbonate in the ICU: An international observational study.

ABSTRACT:

Background

Metabolic acidosis is a major complication of critical illness. However, its current epidemiology and its treatment with sodium bicarbonate given to correct metabolic acidosis in the ICU are poorly understood.

Method

This was an international retrospective observational study in 18 ICUs in Australia, Japan, and Taiwan. Adult patients were consecutively screened, and those with early metabolic acidosis (pH < 7.3 and a Base Excess < -4 mEq/L, within 24-h of ICU admission) were included. Screening continued until 10 patients who received and 10 patients who did not receive sodium bicarbonate in the first 24 h (early bicarbonate therapy) were included at each site. The primary outcome was ICU mortality, and the association between sodium bicarbonate and the clinical o

SUBMITTER: Fujii T 

PROVIDER: S-EPMC7851901 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature