Mitochondrial morphology and activity regulate furrow ingression and contractile ring dynamics in Drosophila cellularization.

ABSTRACT: Mitochondria are maternally inherited in many organisms. Mitochondrial morphology and activity regulation is essential for cell survival, differentiation, and migration. An analysis of mitochondrial dynamics and function in morphogenetic events in early metazoan embryogenesis has not been carried out. In our study we find a crucial role of mitochondrial morphology regulation in cell formation in Drosophila embryogenesis. We find that mitochondria are small and fragmented and translocate apically on microtubules and distribute progressively along the cell length during cellularization. Embryos mutant for the mitochondrial fission protein, Drp1 (dynamin-related protein 1), die in embryogenesis and show an accumulation of clustered mitochondria on the basal side in cellularization. Add

SUBMITTER: Chowdhary S 

PROVIDER: S-EPMC7851960 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature