Multi-omic molecular profiling reveals potentially targetable abnormalities shared across multiple histologies of brain metastasis.

ABSTRACT: The deadly complication of brain metastasis (BM) is largely confined to a relatively narrow cross-section of systemic malignancies, suggesting a fundamental role for biological mechanisms shared across commonly brain metastatic tumor types. To identify and characterize such mechanisms, we performed genomic, transcriptional, and proteomic profiling using whole-exome sequencing, mRNA-seq, and reverse-phase protein array analysis in a cohort of the lung, breast, and renal cell carcinomas consisting of BM and patient-matched primary or extracranial metastatic tissues. While no specific genomic alterations were associated with BM, correlations with impaired cellular immunity, upregulated oxidative phosphorylation (OXPHOS), and canonical oncogenic signaling pathways including phosphoinositide 3-

SUBMITTER: Fukumura K 

PROVIDER: S-EPMC7852029 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature