IsomiR_Window: a system for analyzing small-RNA-seq data in an integrative and user-friendly manner.

ABSTRACT:

Background

IsomiRs are miRNA variants that vary in length and/or sequence when compared to their canonical forms. These variants display differences in length and/or sequence, including additions or deletions of one or more nucleotides (nts) at the 5' and/or 3' end, internal editings or untemplated 3' end additions. Most available tools for small RNA-seq data analysis do not allow the identification of isomiRs and often require advanced knowledge of bioinformatics. To overcome this, we have developed IsomiR Window, a platform that supports the systematic identification, quantification and functional exploration of isomiR expression in small RNA-seq datasets, accessible to users with no computational skills.

Methods

IsomiR Window enables the discovery of isomiRs and identific

SUBMITTER: Vasconcelos AM 

PROVIDER: S-EPMC7852101 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature