Effects of short-term methionine and cysteine restriction and enrichment with polyunsaturated fatty acids on oral glucose tolerance, plasma amino acids, fatty acids, lactate and pyruvate: results from a pilot study.

ABSTRACT:

Objective

In this 7-day pilot study we randomized healthy, normal-weight men and women to either a dietary intervention with methionine and cysteine restriction enriched in PUFA (Met/Cys_low + PUFA, n = 7) or with high contents of methionine, cysteine and SFA (Met/Cys_high + SFA, n = 7). The objective was to describe the short-term responses in oral glucose tolerance, amino acid profile, total fatty acid profile, pyruvate and lactate following a Met/Cys_low + PUFA diet vs. Met/Cys_high + SFA.

Results

The diet groups consisted of five women and two men, aged 20-38 years. After the 7-d intervention median pre- and post-oral glucose tolerance test (OGTT) glucose concentrations were 5 mmol/L and 4 mmol/L respectively in the Met/Cys_low

SUBMITTER: Olsen T 

PROVIDER: S-EPMC7852127 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature