The <i>in-silico</i> characterization of the <i>Caenorhabditis elegans</i> matrisome and proposal of a novel collagen classification.

ABSTRACT: Proteins are the building blocks of life. While proteins and their localization within cells and sub-cellular compartments are well defined, the proteins predicted to be secreted to form the extracellular matrix - or matrisome - remain elusive in the model organism C. elegans. Here, we used a bioinformatic approach combining gene orthology and protein structure analysis and an extensive curation of the literature to define the C. elegans matrisome. Similar to the human genome, we found that 719 out of ~20,000 genes (~4%) of the C. elegans genome encodes matrisome proteins, including 181 collagens, 35 glycoproteins, 10 proteoglycans, and 493 matrisome-associated proteins. We report that 173 out of the 181 collagen genes are unique to nematodes and are predicted to encod

SUBMITTER: Teuscher AC 

PROVIDER: S-EPMC7852208 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature