Cartilage-like composition of keloid scar extracellular matrix suggests fibroblast mis-differentiation in disease.

ABSTRACT: Following wound damage to the skin, the scarring spectrum is wide-ranging, from a manageable normal scar through to pathological keloids. The question remains whether these fibrotic lesions represent simply a quantitative extreme, or alternatively, whether they are qualitatively distinct. A three-way comparison of the extracellular matrix (ECM) composition of normal skin, normal scar and keloids was performed using quantitative discovery-based proteomics. This approach identified 40 proteins that were significantly altered in keloids compared to normal scars, and strikingly, 23 keloid-unique proteins. The major alterations in keloids, when functionally grouped, showed many changes in proteins involved in ECM assembly and fibrillogenesis, but also a keloid-associated loss of proteases, and

SUBMITTER: Barallobre-Barreiro J 

PROVIDER: S-EPMC7852214 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature