SARS-CoV-2 recruits a haem metabolite to evade antibody immunity.
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ABSTRACT:
SUBMITTER: Rosa A
PROVIDER: S-EPMC7852234 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Publications
SARS-CoV-2 recruits a haem metabolite to evade antibody immunity.
Rosa Annachiara A Pye Valerie E VE Graham Carl C Muir Luke L Seow Jeffrey J Ng Kevin W KW Cook Nicola J NJ Rees-Spear Chloe C Parker Eleanor E Dos Santos Mariana Silva MS Rosadas Carolina C Susana Alberto A Rhys Hefin H Nans Andrea A Masino Laura L Roustan Chloe C Christodoulou Evangelos E Ulferts Rachel R Wrobel Antoni A Short Charlotte-Eve CE Fertleman Michael M Sanders Rogier W RW Heaney Judith J Spyer Moira M Kjær Svend S Riddell Andy A Malim Michael H MH Beale Rupert R MacRae James I JI Taylor Graham P GP Nastouli Eleni E van Gils Marit J MJ Rosenthal Peter B PB Pizzato Massimo M McClure Myra O MO Tedder Richard S RS Kassiotis George G McCoy Laura E LE Doores Katie J KJ Cherepanov Peter P
medRxiv : the preprint server for health sciences 20210126
The coronaviral spike is the dominant viral antigen and the target of neutralizing antibodies. We show that SARS-CoV-2 spike binds biliverdin and bilirubin, the tetrapyrrole products of haem metabolism, with nanomolar affinity. Using cryo-electron microscopy and X-ray crystallography we mapped the tetrapyrrole interaction pocket to a deep cleft on the spike N-terminal domain (NTD). At physiological concentrations, biliverdin significantly dampened the reactivity of SARS-CoV-2 spike with immune s ...[more]
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