Structural similarity-based prediction of host factors associated with SARS-CoV-2 infection and pathogenesis.

ABSTRACT: The current pandemic resulted from SARS-CoV-2 still remains as the major public health concern globally. The precise mechanism of viral pathogenesis is not fully understood, which remains a major hurdle for medical intervention. Here we generated an interactome profile of protein-protein interactions based on host and viral protein structural similarities information. Further computational biological study combined with Gene enrichment analysis predicted key enriched pathways associated with viral pathogenesis. The results show that axon guidance, membrane trafficking, vesicle-mediated transport, apoptosis, clathrin-mediated endocytosis, Vpu mediated degradation of CD4 T cell, and interferon-gamma signaling are key events associated in SARS-CoV-2 life cycle. Further, degree centrality anal

SUBMITTER: Tiwari R 

PROVIDER: S-EPMC7852281 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature