Exacerbated age-related hearing loss in mice lacking the p43 mitochondrial T3 receptor.

ABSTRACT:

Background

Age-related hearing loss (ARHL), also known as presbycusis, is the most common sensory impairment seen in elderly people. However, the cochlear aging process does not affect people uniformly, suggesting that both genetic and environmental (e.g., noise, ototoxic drugs) factors and their interaction may influence the onset and severity of ARHL. Considering the potential links between thyroid hormone, mitochondrial activity, and hearing, here, we probed the role of p43, a N-terminally truncated and ligand-binding form of the nuclear receptor TRα1, in hearing function and in the maintenance of hearing during aging in p43^-/- mice through complementary approaches, including in vivo electrophysiological recording, ultrastructural assessments, biochemistry, and molecu

SUBMITTER: Affortit C 

PROVIDER: S-EPMC7852282 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature