Ontology highlight
ABSTRACT:
SUBMITTER: Su X
PROVIDER: S-EPMC7852352 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Journal of hematology & oncology 20210202 1
Genetic heterogeneity of tumor is closely related to its clonal evolution, phenotypic diversity and treatment resistance, and such heterogeneity has only been characterized at single-cell sub-chromosomal scale in liver cancer. Here we reconstructed the single-variant resolution clonal evolution in human liver cancer based on single-cell mutational profiles. The results indicated that key genetic events occurred early during tumorigenesis, and an early metastasis followed by independent evolution ...[more]