In modern times, how important are breast cancer stage, grade and receptor subtype for survival: a population-based cohort study.

ABSTRACT:

Background

In breast cancer, immunohistochemistry (IHC) subtypes, together with grade and stage, are well-known independent predictors of breast cancer death. Given the immense changes in breast cancer treatment and survival over time, we used recent population-based data to test the combined influence of IHC subtypes, grade and stage on breast cancer death.

Methods

We identified 24,137 women with invasive breast cancer aged 20 to 74 between 2005 and 2015 in the database of the Cancer Registry of Norway. Kaplan-Meier curves, mortality rates and adjusted hazard ratios for breast cancer death were estimated by IHC subtypes, grade, tumour size and nodal status during 13 years of follow-up.

Results

Within all IHC subtypes, grade, tumour size and nodal status were independ

SUBMITTER: Johansson ALV 

PROVIDER: S-EPMC7852363 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature