Identification of potential biomarkers for abdominal pain in IBS patients by bioinformatics approach.

ABSTRACT:

Background

Irritable bowel syndrome (IBS) is the most common functional gastrointestinal disease characterized by chronic abdominal discomfort and pain. The mechanisms of abdominal pain, as a relevant symptom, in IBS are still unclear. We aimed to explore the key genes and neurobiological changes specially involved in abdominal pain in IBS.

Methods

Gene expression data (GSE36701) was downloaded from Gene Expression Omnibus database. Fifty-three rectal mucosa samples from 27 irritable bowel syndrome with diarrhea (IBS-D) patients and 40 samples from 21 healthy volunteers as controls were included. Differentially expressed genes (DEGs) between two groups were identified using the GEO2R online tool. Functional enrichment analysis of DEGs was performed on the DAVID database. The

SUBMITTER: Lin Z 

PROVIDER: S-EPMC7852366 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature