High-throughput small molecule screening reveals Nrf2-dependent and -independent pathways of cellular stress resistance.

ABSTRACT: Aging is the dominant risk factor for most chronic diseases. Development of antiaging interventions offers the promise of preventing many such illnesses simultaneously. Cellular stress resistance is an evolutionarily conserved feature of longevity. Here, we identify compounds that induced resistance to the superoxide generator paraquat (PQ), the heavy metal cadmium (Cd), and the DNA alkylator methyl methanesulfonate (MMS). Some rescue compounds conferred resistance to a single stressor, while others provoked multiplex resistance. Induction of stress resistance in fibroblasts was predictive of longevity extension in a published large-scale longevity screen in Caenorhabditis elegans, although not in testing performed in worms and flies with a more restricted set of compounds. Transcri

SUBMITTER: Lombard DB 

PROVIDER: S-EPMC7852388 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature