Multiscale modeling of twitch contractions in cardiac trabeculae.

ABSTRACT: Understanding the dynamics of a cardiac muscle twitch contraction is complex because it requires a detailed understanding of the kinetic processes of the Ca2+ transient, thin-filament activation, and the myosin-actin cross-bridge chemomechanical cycle. Each of these steps has been well defined individually, but understanding how all three of the processes operate in combination is a far more complex problem. Computational modeling has the potential to provide detailed insight into each of these processes, how the dynamics of each process affect the complexity of contractile behavior, and how perturbations such as mutations in sarcomere proteins affect the complex interactions of all of these processes. The mechanisms involved in relaxation of tension during a cardiac twitch have been parti

SUBMITTER: Mijailovich SM 

PROVIDER: S-EPMC7852458 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature