Retinal Thickness Changes Over Time in a Murine AD Model APP ^NL-F/NL-F.

ABSTRACT: Background: Alzheimer's disease (AD) may present retinal changes before brain pathology, suggesting the retina as an accessible biomarker of AD. The present work is a diachronic study using spectral domain optical coherence tomography (SD-OCT) to determine the total retinal thickness and retinal nerve fiber layer (RNFL) thickness in an APP^NL-F/NL-F mouse model of AD at 6, 9, 12, 15, 17, and 20 months old compared to wild type (WT) animals. Methods: Total retinal thickness and RNFL thickness were determined. The mean total retinal thickness was analyzed following the Early Treatment Diabetic Retinopathy Study sectors. RNFL was measured in six sectors of axonal ring scans around the optic nerve. Results: In the APP^NL-F/NL-F group compared to WT anim

SUBMITTER: Salobrar-Garcia E 

PROVIDER: S-EPMC7852550 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature