A novel allosteric modulator of the cannabinoid CB₁ receptor ameliorates hyperdopaminergia endophenotypes in rodent models.

ABSTRACT: The endocannabinoid system (eCBs) encompasses the endocannabinoids, their synthetic and degradative enzymes, and cannabinoid (CB) receptors. The eCBs mediates inhibition of neurotransmitter release and acts as a major homeostatic system. Many aspects of the eCBs are altered in a number of psychiatric disorders including schizophrenia, which is characterized by dysregulation of dopaminergic signaling. The GluN1-Knockdown (GluN1KD) and Dopamine Transporter Knockout (DATKO) mice are models of hyperdopaminergia, which display abnormal psychosis-related behaviors, including hyperlocomotion and changes in pre-pulse inhibition (PPI). Here, we investigate the ability of a novel CB₁ receptor (CB₁R) allosteric modulator, ABM300, to ameliorate these dysregulated behaviors. ABM30

SUBMITTER: Mielnik CA 

PROVIDER: S-EPMC7852560 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature