Multimodal investigation of dopamine D₂/D₃ receptors, default mode network suppression, and cognitive control in cocaine-use disorder.

ABSTRACT: Stimulant-use disorders have been associated with lower availability of dopamine type-2 receptors (D2R) and greater availability of type-3 receptors (D3R). Links between D2R levels, cognitive performance, and suppression of the default mode network (DMN) during executive functioning have been observed in healthy and addicted populations; however, there is limited evidence regarding a potential role of elevated D3R in influencing cognitive control processes in groups with and without addictions. Sixteen individuals with cocaine-use disorder (CUD) and 16 healthy comparison (HC) participants completed [¹¹C]-(+)-PHNO PET imaging of D2R and D3R availability and fMRI during a Stroop task of cognitive control. Independent component analysis was performed on fMRI data to assess DMN supp

SUBMITTER: Worhunsky PD 

PROVIDER: S-EPMC7852666 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature