A robust and reproducible connectome fingerprint of ketamine is highly associated with the connectomic signature of antidepressants.

ABSTRACT: Over the past decade, various N-methyl-D-aspartate modulators have failed in clinical trials, underscoring the challenges of developing novel rapid-acting antidepressants based solely on the receptor or regional targets of ketamine. Thus, identifying the effect of ketamine on the brain circuitry and networks is becoming increasingly critical. In this longitudinal functional magnetic resonance imaging study of data from 265 participants, we used a validated predictive model approach that allows the full assessment of brain functional connectivity, without the need for seed selection or connectivity summaries. First, we identified a connectome fingerprint (CFP) in healthy participants (Cohort A, n = 25) during intravenous infusion of a subanesthetic dose of ketamine, compared to normal salin

SUBMITTER: Abdallah CG 

PROVIDER: S-EPMC7852889 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature