Value of biomarkers in predicting mortality in older medical emergency department patients: a Dutch prospective study.

ABSTRACT:

Objective

Older emergency department (ED) patients are at high risk of mortality, and it is important to predict which patients are at highest risk. Biomarkers such as lactate, high-sensitivity cardiac troponin T (hs-cTnT), N-terminal pro-B-type natriuretic peptide (NT-proBNP), D-dimer and procalcitonin may be able to identify those at risk. We aimed to assess the discriminatory value of these biomarkers for 30-day mortality and other adverse outcomes.

Design

Prospective cohort study. On arrival of patients, five biomarkers were measured. Area under the curves (AUCs) and interval likelihood ratios (LRs) were calculated to investigate the discriminatory value of the biomarkers.

Setting

ED in the Netherlands.

Participants

Older (≥65 years) medical ED patients, re

SUBMITTER: Zelis N 

PROVIDER: S-EPMC7852925 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature