A 500-year tale of co-evolution, adaptation, and virulence: Helicobacter pylori in the Americas.

ABSTRACT: Helicobacter pylori is a common component of the human stomach microbiota, possibly dating back to the speciation of Homo sapiens. A history of pathogen evolution in allopatry has led to the development of genetically distinct H. pylori subpopulations, associated with different human populations, and more recent admixture among H. pylori subpopulations can provide information about human migrations. However, little is known about the degree to which some H. pylori genes are conserved in the face of admixture, potentially indicating host adaptation, or how virulence genes spread among different populations. We analyzed H. pylori genomes from 14 countries in the Americas, strains from the Iberian Peninsula, and public genomes from Europe, Africa, and Asia, to investigate how admixture varies

SUBMITTER: Munoz-Ramirez ZY 

PROVIDER: S-EPMC7853065 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature