Recirculating IL-1R2⁺ Tregs fine-tune intrathymic Treg development under inflammatory conditions.

ABSTRACT: The vast majority of Foxp3⁺ regulatory T cells (Tregs) are generated in the thymus, and several factors, such as cytokines and unique thymic antigen-presenting cells, are known to contribute to the development of these thymus-derived Tregs (tTregs). Here, we report the existence of a specific subset of Foxp3⁺ Tregs within the thymus that is characterized by the expression of IL-1R2, which is a decoy receptor for the inflammatory cytokine IL-1. Detailed flow cytometric analysis of the thymocytes from Foxp3^hCD2xRAG1^GFP reporter mice revealed that the IL-1R2⁺ Tregs are mainly RAG1^GFP- and CCR6⁺CCR7^-, demonstrating that these Tregs are recirculating cells entering the thymus from the periphery and that they

SUBMITTER: Nikolouli E 

PROVIDER: S-EPMC7853075 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature