Distinct Distribution of RTN1A in Immune Cells in Mouse Skin and Lymphoid Organs.

ABSTRACT: The endoplasmic reticulum-associated protein reticulon 1A (RTN1A) is primarily expressed in neuronal tissues but was recently identified also specifically in cells of the dendritic cell (DC) lineage, including epidermal Langerhans cells (LCs) and dermal DCs in human skin. In this study, we found that in mice major histocompatibility complex class II (MHCII)⁺CD207⁺ LCs but not dermal DCs express RTN1A. Further, RTN1A expression was identified in CD45⁺MHCII⁺CD207⁺ cells of the lymph node and spleen but not in the thymus. Of note, RTN1A was expressed in CD207 ^low LCs in adult skin as well as emigrated LCs and DCs in lymph nodes and marginally in CD207 ^hi cells. Ontogeny studies revealed that RTN1A expre

SUBMITTER: Cichon MA 

PROVIDER: S-EPMC7853085 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature