Clinically and biologically relevant subgroups of Wilms tumour defined by genomic and epigenomic analyses.

ABSTRACT:

Background

Although cure rates for Wilms tumours (WT) are high, many patients receive therapy with attendant long-term complications. Our goal was to stratify WT using genome-wide analyses to identify candidate molecular features for patients who would benefit from a reduction in therapy.

Methods

We generated DNA methylation and exome sequencing data on WT-kidney pairs (n = 57) and unpaired tumours (n = 27) collected either at our centre or by the Children's Oncology Group. Samples were divided into a discovery set (n = 32) and validation set (n = 52).

Results

Analysis of DNA methylation revealed two subgroups of WT with distinct features. Subgroup A has a similar DNA methylation profile to mature kidney, while Subgroup B has genome-wide dysregulation of DNA methylati

SUBMITTER: Brzezinski J 

PROVIDER: S-EPMC7853092 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature