Lithium modulates striatal reward anticipation and prediction error coding in healthy volunteers.

ABSTRACT: Lithium is one of the most effective mood-stabilizing medications in bipolar disorder. This study was designed to test whether lithium administration may stabilize mood via effects on reward processing. It was hypothesized that lithium administration would modulate reward processing in the striatum and affect both anticipation and outcome computations. Thirty-seven healthy human participants (18 males, 33 with suitable fMRI data) received 11 (±1) days of lithium carbonate or placebo intervention (double-blind), after which they completed the monetary incentive delay task while fMRI data were collected. The monetary incentive delay task is a robust task with excellent test-retest reliability and is well suited to investigate different phases of reward processing within the caudate and nucle

SUBMITTER: Volman I 

PROVIDER: S-EPMC7853118 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature