Yin Yang 1 is required for PHD finger protein 20-mediated myogenic differentiation in vitro and in vivo.

ABSTRACT: The development of skeletal muscle requires progression of a highly ordered cascade of events comprising myogenic lineage commitment, myoblast proliferation, and terminal differentiation. The process of myogenesis is controlled by several myogenic transcription factors that act as terminal effectors of signaling cascades and produce appropriate developmental stage-specific transcripts. PHD finger protein 20 (PHF20) is a multidomain protein and subunit of a lysine acetyltransferase complex that acetylates histone H4 and p53, but its function is unclear. Notably, it has been reported that PHF20 knockout mice die shortly after birth and display a wide variety of phenotypes within the skeletal and hematopoietic systems. Therefore, the putative role of PHF20 in myogenic differentiation was furt

SUBMITTER: Lee H 

PROVIDER: S-EPMC7853144 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature