Antiviral activities and applications of ribosomally synthesized and post-translationally modified peptides (RiPPs).

ABSTRACT: The emergence and re-emergence of viral epidemics and the risks of antiviral drug resistance are a serious threat to global public health. New options to supplement or replace currently used drugs for antiviral therapy are urgently needed. The research in the field of ribosomally synthesized and post-translationally modified peptides (RiPPs) has been booming in the last few decades, in particular in view of their strong antimicrobial activities and high stability. The RiPPs with antiviral activity, especially those against enveloped viruses, are now also gaining more interest. RiPPs have a number of advantages over small molecule drugs in terms of specificity and affinity for targets, and over protein-based drugs in terms of cellular penetrability, stability and size. Moreover, the great e

SUBMITTER: Fu Y 

PROVIDER: S-EPMC7853169 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature