A Modified Tumor-Node-Metastasis Classification for Primary Operable Colorectal Cancer.

ABSTRACT:

Background

The American Joint Committee on Cancer (AJCC) 8th tumor-node-metastasis (TNM) classification for colorectal cancer (CRC) has limited ability to predict prognosis.

Methods

We included 45 379 eligible stage I-III CRC patients from the Surveillance, Epidemiology, and End Results Program. Patients were randomly assigned individually to a training (n = 31 772) or an internal validation cohort (n = 13 607). External validation was performed in 10 902 additional patients. Patients were divided according to T and N stage permutations. Survival analyses were conducted by a Cox proportional hazard model and Kaplan-Meier analysis, with T1N0 as the reference. Area under receiver operating characteristic curve and Akaike information criteria were ap

SUBMITTER: Zhang C 

PROVIDER: S-EPMC7853182 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature